ATX inhibitor 5 是有效的口服活性 autotaxin (ATX) 抑制剂，IC50 为 15.3 nM。AATX inhibitor 5 具有抗肝纤维化作用，并显着降低 CCl4 诱导的肝纤维化水平。
货号:ajcx33654
CAS:2402772-45-4
分子式:C22H18ClF3N6O
分子量：474.87
溶解度:DMSO : 250 mg/mL (526.46 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].

ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC)[1].ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β[1].

ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently[1].

[1]. Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904.