Ned K 是一种烟酸腺嘌呤二核苷酸磷酸 (NAADP) 拮抗剂。
货号:ajcx27318
CAS:2250019-90-8
分子式:C31H31N5O3
分子量：521.61
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

NAADP inhibitor. Prevents Ca2+ oscillations in rat cardiomyocytes in vitro during simulated ischemia and reperfusion, but exhibits no significant effect on Ca2+ sparks. Significantly reduces infarct size in rat cardiac ischemia/reperfusion model in vivo.

Davidson et al (2015) Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc.Res. 108 357 PMID:26395965