MutantIDH1-IN-2是一种突变型异柠檬酸脱氢酶(IDH)蛋白抑制剂,在LS-MS生物化学检测中IC50值为<22nM,荧光生物化学检测中IC50值为16.6nM。
CAS：1429176-69-1
分子式：C24H31F2N5O2
分子量：459.53
纯度：98%
存储：Store at -20°C

Background:

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).

[1]. Huangshu, et al. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation