Cdc7-IN-1 (Compound 13) 是一种高效、选择性的 ATP 竞争性的 Cdc7 激酶抑制剂，在 1 mM ATP 存在时对 Cdc7 作用的 IC50 值为 0.6 nM，具有解离率低的特质。Cdc7-IN-1 能高效地抑制癌细胞中的 Cdc7，诱导细胞死亡。
CAS：1402055-25-7
分子式：C21H16ClN3O4
分子量：409.82
纯度：98%
存储：Store at -20°C

Background:

Cdc7-IN-1 (Compound 13) is a highly potent, selective and ATP competitive inhibitor of Cdc7 kinase, with an IC50 value of 0.6 nM at 1 mM ATP and with slow off-rate characteristics. Cdc7-IN-1 potently inhibits Cdc7 activity in cancer cells, and effectively induces cell death[1]. IC50: 0.6 nM (Cdc7, at 1 mM ATP)[1]

[1]. Irie T, et al. Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors. Eur J Med Chem. 2017 Apr 21;130:406-418.