Acevaltrate从Valerianaglechomifolia中分离,抑制大鼠肾和脑半球中Na+/K+-ATP酶活性,IC50分别为22.8±1.1μM和42.3±1.0μM。
CAS:25161-41-5
分子式:C24H32O10
分子量:480.5
纯度:98%
存储:Store at -20°C
Background:
Acevaltrate, isolated from Valeriana glechomifolia, inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8±1.1 μM and 42.3±1.0 μM, respectively[1].
Acevaltrate differentiallys inhibit the activity of rat P-type ATPases in vitro. 60.7±7.3% inhibition of the rat H+/K+-ATPase is achieved at 100 µM[1].
[1]. Bettero GM, et al. In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases. Planta Med. 2011 Oct;77(15):1702-6.