Fezolinetant(ESN-364)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	1629229-37-3
规格:	98%
分子量:	358.39

包装与价格：

包装	价格(元)
1mg	询价
5mg	询价
10mg	询价
25mg	询价
50mg	询价
100mg	询价

Fezolinetant是一种神经激肽-3受体(neurokinin3receptor)拮抗剂，可用于更年期潮热的研究。
CAS：1629229-37-3
分子式：C16H15FN6OS
分子量：358.39
纯度：98%
存储：Store at -20°C

Background:

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

Fezolinetant (ESN364, 1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovarectomized ewe. ESN364 represses the pulse pattern of LH in all treated animals. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. ESN364 (10, 25, 50 mg/kg, orally) also blocks the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys[1].

[1]. Fraser GL, et al. The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. Endocrinology. 2015 Nov;156(11):4214-25.