Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions.
CAS：5874-97-5
分子式：C11H17NO3.1/2H2SO4
分子量：260.3
纯度：98%
存储：Store at -20°C

Background:

Metaproterenol is a β2-adrenergic receptor (β2-AR) agonist with bronchodilator actions. It inhibits TGF-α-induced hepatocyte DNA synthesis and proliferation in vitro (IC50 = 15 nM), an effect that is reversed by the β2-AR antagonist butoxamine but not the β1-AR antagonist metoprolol . Metaproterenol dose-dependently relaxes lung strips and increases heart rate and inotropy of right atria and left atria, respectively, isolated from guinea pig (pD2s = 6.4, 7.08, and 6.61, respectively). Formulations containing metaproterenol were previously used as long-acting bronchodilators for the treatment of asthma.