c-met-IN-1 (compound 16) 是一种高效选择性的 c-Met 抑制剂，IC50 值为 1.1 nM，具有抗肿瘤活性。
CAS：2084836-84-8
分子式：C35H37FN6O5
分子量：640.7
纯度：98%
存储：Store at -20°C

Background:

c-met-IN-1 (compound 16) is a potent and selective c-Met inhibitor, with IC50 of 1.1 nM, with antitumor activity.[1]. IC50: 1.1 nM (c-Met)[1]

c-met-IN-1 (compound 16) exhibits high selectivity and remarkable cytotoxicity against HT-29, MKN-45 and A549 cells with IC50 values of 0.08 μM, 0.22 μM and 0.07 μM, respectively[1].

[1]. Wang X, et al. Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors. Bioorg Med Chem. 2017 Feb 1;25(3):886-896.