Salinomycin sodium (also known as Procoxacin, AHR-3096) is a potent
antibacterial and coccidiostat ionophore therapeutic agent with
potential anticancer activities by targeting stem cells. Salinomycin
(Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem
cells at least 100 times more effectively than another popular
anti-cancer compound (paclitaxel) in mice. The mechanism of action by
which salinomycin (Procoxacin) kills cancer stem cells specifically
remains unknown, but is thought to be due to its action as a potassium
ionophore due to the detection of Nigericin in the same compound screen.
Salinomycin has high toxicity and a narrow therapeutic window which may
limit its clinical use.
纯度:≥98%
CAS:55721-31-8