FDI6 是FOXM1抑制剂。它能够作用于 MCF-7 乳腺癌细胞中，直接与 FOXM1 蛋白结合，从靶基因组中取代 FOXM1，并诱导随后的转录下调。
产品描述
FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6 binds to the FOXM1 protein and specifically downregulates FOXM1-activated genes.
体外活性
FDI-6 specifically downregulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-PCR. This small molecule-mediated effect is selective for FOXM1-controlled genes with no effect on genes regulated by homologous forkhead family factors.
Cas No.
313380-27-7
分子式
C19H11F4N3OS2
分子量
437.43
别名
FDI 6;FDI6;FDI-6
储存和溶解度
DMSO:10 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
