LY-3177833 抑制CDC7和pMCM2，IC50值分别为 3.3 nM 和 290 nM。
产品描述
LY-3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM)
体内活性
LY-3177833 inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM).?LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day
Cas No.
1627696-51-8
分子式
C16H12FN5O
分子量
309.304
别名
LY-3177833;LY3177833
储存和溶解度
DMSO:30 mg/mL (96.99 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
