NMI 8739 是 D2 自身受体的激动剂。 NMI 8739 减少 NO 的产生并引起 CCL-20、MCP-1 和 IL-6 释放的浓度依赖性抑制。
产品描述
NMI 8739 is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
体外活性
NMI 8739 (2 μM) significantly inhibits IL-6 and CCL-20 release up to 49% and 37%, respectivel. NMI 8739 suppresses the production of PGE2 in a concentration-dependent manner with 25.3%, 75% reduction at doses of 100 nM and 1 μM, respectively[2].
Cas No.
129024-87-9
分子式
C30H41NO3
分子量
463.65
别名
n-docosahexaenoyl dopamine;NMI 8739
储存和溶解度
Ethanol:90 mg/mL (194.1 mM),Need ultrasonic
DMSO:90 mg/mL (194.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
