TAK-071是一种新颖的和高度选择性的毒蕈碱乙酰胆碱受体 1 正变构调节剂，激活M1R的EC50为520nM。
产品描述
TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).
体内活性
In rats, TAK-071(0.3 mg/kg) increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits, TAK-071(10 mg/kg) also induce diarrhea .
Cas No.
1820812-16-5
分子式
C24H24FN3O3
分子量
421.46
别名
TAK-071
储存和溶解度
DMSO:134 mg/mL(317.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
