A-867744 是一种有效且选择性的 II 型正向变构调节剂，对α7 nAChR 的EC50值为 1.0 μM.
产品描述
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
体外活性
A-867744(Compound 19), a novel type II PAM with good potency and selectivity.?Compound 19 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs.?In a rodent model of sensory gating, 19 normalized gating deficits.?These results suggest that 19 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs[2].
Cas No.
1000279-69-5
分子式
C20H19ClN2O3S
分子量
402.89
别名
A-867744
储存和溶解度
DMSO:100 mg/mL (248.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
