CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM，详细信息请参考专利文献 US20180000819A1 中的化合物 1。
产品描述
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM) extracted from patent US20180000819A1 (Compound 1).
体外活性
CDK4/6-IN-2 inhibits H441, H358, PC3, MV-4-11, JeKo-1, SW780, and HGC-27 cells (IC50s: 147.8, 290.9, 260.5, 139, 36.98, 162.5, and 316.4 nM).
Cas No.
1800506-48-2
分子式
C27H32F2N8
分子量
506.59
储存和溶解度
DMSO:5mg/mL (9.87 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
