PF-04745637 是TRPA1的选择性拮抗剂，对人 TRPA1 的IC50为 17 nM。
产品描述
PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].
体内活性
PF-04745637 (topically applied; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1].
Cas No.
1917294-46-2
分子式
C27H32ClF3N2O2
分子量
509
别名
PF 4745637;PF-4745637;PF4745637;PF 04745637
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
