LP-922056 是 Notum PectinacetylesteRase 的抑制剂，对人和小鼠的 EC50 值分别为 21 nM 和 55 nM。
产品描述
LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
体外活性
LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling[2].
体内活性
In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μMoh while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/minokg[1]. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell[2].
Cas No.
1365060-22-5
分子式
C11H9ClN2O2S2
分子量
300.78
储存和溶解度
DMSO:120 mg/mL (398.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
