IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导，还可以防止实验性腹主动脉瘤的发展。它抑制 MAPK 和 p65 NF-Κb 磷酸化和 TLR4 依赖性促炎蛋白的表达。

IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.

IAXO-102 (10 μM, for 17 hours) suppresses LPS induced pro-inflammatory proteins MCP-1 and IL-8 production in HUVEC. IAXO-102 (1-10 μM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells.

IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II-induced increase in aortic diameter in mice.

1115270-63-7

C35H71NO5

585.94

DMSO:< 1 mg/mL (insoluble or slightly soluble)
Ethanol:45 mg/mL (76.8 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years