HBX 19818 是一种特异性泛素特异性蛋白酶 7 (USP7) 抑制剂，IC50值为 28.1 μM。
产品描述
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
体外活性
HBX 19818 inhibits HCT116 proliferation in a dose-dependent manner (IC50: ～2 μM). HBX 19818 selectively inhibits USP7 (IC50: ～6 μM in human cancer cells). HBX 19818 (1.5, 4, 12, 36, or 100 μM) inhibits USP7 deubiquitination of polyubiquitinated p53. HBX 19818 displays no effects on USP8, USP5, USP10, CYLD, UCH-L1, UCH-L3, or on SENP1, a SUMO protease (IC50s of >200 μM). HBX 19818 (30 μM) also causes significantly higher levels of Mdm2 polyubiquitinated forms in USP7-overproducing HEK293 cells than those in DMSO-treated control cells.
Cas No.
1426944-49-1
分子式
C25H28ClN3O
分子量
421.96
储存和溶解度
DMSO:20 mg/mL (47.40 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
