Xanthohumol and xanthohumol D are potent inducers of quinone reductase, suggests that they could be used as chemoprevention agents.

Six metabolites were obtained as a result of transformation of xanthohumol (1) by selected fungal cultures. Their structures were established on the basis of their spectral data. One of them: 2"-(2'''-hydroxyisopropyl)-dihydrofurano-[4",5":3',4']-4',2-dihydroxy-6'-methoxy-α±,β-dihydrochalcone (6) has not been previously reported in the literature. The antioxidant properties of hops flavonoids and Xanthohumol Derivatives were investigated using the 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The effects of these compounds on proliferation of MCF-7, PC-3 and HT-29 human cancer cell lines were determined by the SRB assay.

274675-25-1

C21H22O6

370.4

黄腐醇 D

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years