Saroglitazar 是 PPAR 的激动剂，对 PPARα 和 PPARγ 的 EC50 值为 0.65 pM 和 3 nM。
产品描述
Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.
体内活性
In db/db mice, Saroglitazar (0.01-3 mg/kg; orally) reduces serum triglycerides, free fatty acids, and glucose in a dose-dependent manner (ED50 = 0.05, 0.19, and 0.19 mg/kg). Saroglitazar (1 mg/kg) significantly reduces serum insulin and AUC-glucose(91%)[3].
Cas No.
495399-09-2
分子式
C25H29NO4S
分子量
439.57
别名
Lipaglyn
储存和溶解度
DMSO:22.5mg/mL (51.2mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
