Caulophyllogenin 是一种部分 PPARγ 激动剂 (EC50?=?12.6?μM)，来源于 Kalopanax pictus (五加科) 的茎皮。 Caulophyllogenin 抑制促炎细胞因子分泌，可用于预防和治疗炎症性疾病、2 型糖尿病、肥胖和代谢综合征的研究。
产品描述
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the prevention and treatment of inflammatory diseases, type-2 diabetes, obesity and metabolic syndrome.
体外活性
Caulophyllogenin inhibits IL-12 p40, IL-6, and TNF-α with IC50s ranging from 3.3 to 20.0 μM[1].
Cas No.
52936-64-8
分子式
C30H48O5
分子量
488.7
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
