CFI-400945 是一种有效的、选择性的、具有口服活性的 polo 样激酶 4（PLK4；Ki 值为 0.26 nM）的抑制剂。
产品描述
CFI-400945 is an potent, selective and orally active inhibitor of polo-like kinase 4(PLK4; Ki value of 0.26 nM).
体外活性
CFI-400945, a potent and selective PLK4 inhibitor.?Cancer cells treated with CFI-400945 exhibit effects consistent with PLK4 kinase inhibition, including dysregulated centriole duplication, mitotic defects, and cell death[1].
体内活性
Oral administration of CFI-400945 to mice bearing human cancer xenografts results in the significant inhibition of tumor growth at doses that are well tolerated[1].
Cas No.
1338806-73-7
分子式
C33H34N4O3
分子量
534.65
储存和溶解度
DMSO:100 mg/mL (187.04 mM),warmed with 50oC water bath
Ethanol:100 mg/mL (187.04 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
