Belizatinib 是可口服的ALK 和 TRKA、TRKB、TRKC 双重抑制剂，对野生型重组 ALK 的IC50值为0.7?nM。
产品描述
Belizatinib is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
体外活性
In the Clinicalal trials, Belizatinib has antitumor activity.
体内活性
In mouse models, Belizatinib can continuously and effectively inhibit ALK-dependent tumor growth.
Cas No.
1357920-84-3
分子式
C33H44FN5O3
分子量
577.75
别名
TSR-011
储存和溶解度
DMSO:300 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
