H-D-Phe-Pip-Arg-pNAhydrochloride是一种显色底物，在纤维蛋白原α链的N端部分之后形成，纤维蛋白原是凝血酶的天然底物。H-D-Phe-Pip-Arg-pNAhydrochloride对凝血酶有特异性，用于测定抗凝血酶肝素辅因子(AT-III)。使用H-D-Phe-Pip-Arg-pNAhydrochloride进行的AT-III分析灵敏、准确、易于执行。
| Cas No. | 160192-34-7 |
| 别名 | S-2238 hydrochloride |
| Canonical SMILES | O=C(C(N)CC1=CC=CC=C1)N2[C@@H](C(N[C@@H](CCCNC(N)=N)C(NC3=CC=C([N+]([O-])=O)C=C3)=O)=O)CCCC2.Cl |
| 分子式 | C27H37ClN8O5 |
| 分子量 | 589.09 |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | H-D-Phe-Pip-Arg-pNA hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2]. [1]. Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647.
[2]. van Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. |
