JW 642 是一种高效的MAGL抑制剂，对小鼠、大鼠和人源脑细胞膜上MAGL的IC50值分别为7.6nM、14nM和3.7nM。
产品描述
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively).
体外活性
MAGL inhibitor JW 642 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s: 31, 14, and 20.6 μM for mouse, rat, and human brain membranes, respectively).
Cas No.
1416133-89-5
分子式
C21H20F6N2O3
分子量
462.39
储存和溶解度
DMSO:90 mg/mL (194.64mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
