Fezolinetant 是一种神经激肽-3 受体拮抗剂，可用于更年期潮热的研究。
产品描述
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
体内活性
ESN364 inhibits the pulse pattern of LH in all treated animals. ESN364 (10, 25, 50 mg/kg, orally) also block the LH surge and decreases ovarian hormone levels throughout the menstrual cycle in monkeys. ESN364 (5 mg/kg, p.o.) lowers plasma LH, but not FSH, in the castrated monkey. Fezolinetant (1 mg/kg, iv bolus) reversibly inhibits the regular, pulsatile secretion of LH in the ovariectomized ewe [1].
Cas No.
1629229-37-3
分子式
C16H15FN6OS
分子量
358.39
别名
ESN-364
储存和溶解度
DMSO:20 mg/mL (55.81 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
