Enbezotinib 是一种 RET 的抑制剂，可抑制 RET 的自磷酸化。Enbezotinib 可用于癌症的研究。
产品描述
Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer.
体外活性
Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].
体内活性
Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].
Cas No.
2359649-81-1
分子式
C21H21FN6O3
分子量
424.43
储存和溶解度
DMSO:90mg/mL (212mM),ultrasonic and warming and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
