RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂，Kd值为 4 nM，IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。
产品描述
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
体外活性
In the TSZ-induced HT29 cell necroptosis model, RIPK1-IN-7 shows potent cell protection effect (EC50 of 2nM). RIPK1-IN-7 displays considerable activity against several other kinases(Flt4, TrkA, TrkB, TrkC, Axl, HRI, Mer, and MAP4K5 with IC50s of 20, 26, 8, 7, 35, 26, 29, and 27 nM, respectively).
Cas No.
2300982-44-7
分子式
C25H22F3N5O2
分子量
481.47
储存和溶解度
DMSO:60 mg/mL (124.62 mM),Need ultrasonic
H2O:0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
