LY2090314 是GSK-3抑制剂，抑制 GSK-3α (IC50:1.5 nM) 和 GSK-3β (IC50:0.9 nM)。
产品描述
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, and Pancreatic Cancer.
体内活性
LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts. [1]
Cas No.
603288-22-8
分子式
C28H25FN6O3
分子量
512.53
储存和溶解度
DMSO:93 mg/mL (181.5 mM)
Ethanol:2 mg/mL (3.9 mM),warmed
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
