DPTIP 是一种有效的中性鞘磷脂酶 2 抑制剂，IC50 值为 30 nM。
产品描述
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
体外活性
DPTIP (30 μM) decreases exosome release by 50% in astrocytes. DPTIP(0.03-30 μM) dose-dependently blocks EV secretion[1].
体内活性
In mice, DPTIP potently (10 mg/kg; i.p.) inhibits IL-1β-induced astrocyte-derived EV release. Brain concentrations of DPTIP are above its IC50 for neutral sphingomyelinase 2 inhibition for at least 4 h after the administration of DPTIP[2].
Cas No.
351353-48-5
分子式
C21H18N2O3S
分子量
378.44
储存和溶解度
DMSO:245 mg/mL (647.39 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
