IT1t dihydrochloride 抑制 CXCL12/CXCR4 相互作用，IC50 为 2.1 nM。 IT1t dihydrochloride 是 CXCR4 的拮抗剂。
产品描述
IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.
体外活性
AMD11070 shows antagonistic activity as it dose-dependently inhibits the CXCL12-induced intracellular calcium flux This calcium flux is inhibited by IT1t dihydrochloride with an IC50 of 23.1[1].
体内活性
IT1t dihydrochloride reduces the formation of early metastases of TNBC in a zebrafish xenograft model. After CXCR4 silencing, tumor cell invasion at metastatic sites was effectively reduced [3].
Cas No.
1092776-63-0
分子式
C21H36Cl2N4S2
分子量
479.57
储存和溶解度
DMSO:27mg/mL (56.3mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
