PDE4-IN-9

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PDE4-IN-9

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2519450-32-7

PDE4-IN-9 (Compound 5j) 是一种有效的PDE4抑制剂。在体外酶试验中，PDE4-IN-9 对 PDE4 的IC₅₀值 (1.4 μM) 低于亲本咯利普兰 (2.0 μM)。PDE4-IN-9 在 LPS 诱导的哮喘/COPD 和败血症动物模型中也显示出良好的体内活性。

生物活性	PDE4-IN-9 (Compound 5j) is a potent inhibitor ofPDE4. PDE4-IN-9 exhibits lowerIC₅₀value (1.4 μM) againstPDE4than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS^[1].
分子量	328.35
Formula	C₁₅H₁₂N₄O₃S
CAS 号	2519450-32-7
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.