4,9-Anhydrotetrodotoxin is a selective voltage-gatedsodium channel(VGSC) inhibitor that blocks Nav1.1 and Nav1.6 in human brain and induces a hyperpolarizing shift in the voltage dependence of inactivated Nav1.6^[1].

4,9-Anhydrotetrodotoxin (0.01-10000 nM) results in significant blockade of Nav1.6-mediated Na current in the nanomolar range, it also has significant effects on Nav1.1-mediated Na current in human brain sample^[1].

301.25

C₁₁H₁₅N₃O₇

13072-89-4

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