Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) 是一种高效、选择性和口服活性的流感病毒神经氨酸酶 (NA) 抑制剂，对九种 NA 亚型的 IC50 值为 0.9 至 4.3 nM。
| Cas No. | 1041434-82-5 |
| 别名 | 帕拉米韦三水合物; RWJ 270201 trihydrate; BCX 1812 trihydrate |
| 化学名 | (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate |
| Canonical SMILES | CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O |
| 分子式 | C15H34N4O7 |
| 分子量 | 382.45 |
| 溶解度 | ≥ 19.1mg/mL in Water with gentle warming |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes[1][2]. References:
[1]. Babu YS, et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem. 2000 Sep 21;43(19):3482-6.
[2]. Young D, et al. RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13. |
