Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride 是一种具有口服活性的非选择性 β-adrenoceptor 拮抗剂和 5-HT1A 和 5-HT1B 受体的拮抗剂。盐酸阿普洛尔用作抗高血压、抗心绞痛和抗心律失常剂。
| Cas No. | 13707-88-5 |
| 别名 | 盐酸阿普洛尔; (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride |
| 化学名 | (S)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol hydrochloride |
| Canonical SMILES | O[C@H](COC1=CC=CC=C1CC=C)CNC(C)C.Cl |
| 分子式 | C15H23NO2.HCl |
| 分子量 | 285.81 |
| 溶解度 | Soluble to 100 mM in sterile water |
| 储存条件 | Store at 2-8℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.The reference for administration is 10 mg/kg. References:
[1]. Schreiber R et al. Involvement of 5-HT1A receptors in the anxiolytic action of S 14671 in the pigeon conflict test. Pharmacol Biochem Behav. 1995 Jun-Jul;51(2-3):211-5.
[2]. Millan MJ et al. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. J Pharmacol Exp Ther, 1994 Jan, 2 |
