AChE/BChE/MAO-B-IN-1

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CAS NO:

2416910-82-0

AChE/BChE/MAO-B-IN-1 (Compound 10) 是一种可逆的、非时间依赖的AChE、BChE和MAO-B抑制剂，对 hAChE、hBChE 和 hMAO-B 的IC₅₀分别为 7.31、0.56 和 26.1 μM。AChE/BChE/MAO-B-IN-1 能透过血脑屏障，具有神经保护作用且无细胞毒性。

生物活性

AChE/BChE/MAO-B-IN-1 (Compound 10) is a reversible and non-time-dependentAChE,BChEandMAO-Binhibitor withIC₅₀values of 7.31, 0.56 and 26.1 μM for hAChE, hBChE and hMAO-B, respectively. AChE/BChE/MAO-B-IN-1 can cross the BBB and shows neuroprotective effects without cytotoxicity^[1].

IC₅₀& Target

MAO-B

26.1 μM (IC₅₀)

hAChE

7.31 μM (IC₅₀)

hBChE

0.56 μM (IC₅₀)

体外研究
(In Vitro)

AChE/BChE/MAO-B-IN-1 (Compound 10) prevents amyloid β_1-42(Aβ_1-42)-induced neuronal cell death^[1].

分子量

324.42

Formula

C₂₀H₂₄N₂O₂

CAS 号

2416910-82-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.