KRAS inhibitor-12 (compound 6-1) 是一种有效的KRAS G12C抑制剂，IC50为 0.537 μM。KRAS inhibitor-12 在 MIA PaCA-2，A549 细胞中显示出 p-ERK 抑制活性，IC50s 分别为 1.3，3.7 μM。 KRAS inhibitor-12 具有研究胰腺癌，结直肠癌和肺癌的潜力。
| 生物活性 | KRAS inhibitor-12 (compound 6-1) is a potentKRAS G12Cinhibitor with anIC50of 0.537 μM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 μM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
