[Ala11,D-Leu15]-Orexin B(human)

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CAS NO:

532932-99-3

[Ala11,D-Leu15]-Orexin B(human) 是一种有效的，选择性的orexin-2 receptor (OX2)的激动剂。[Ala11,D-Leu15]-Orexin B(human) 对 OX2 (EC₅₀=0.13 nM) 比对 OX1 (52 nM) 高出 400 倍的选择性。

生物活性

[Ala11,D-Leu15]-Orexin B(human) is a potent and selectiveorexin-2 receptor (OX2)agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC₅₀=0.13 nM) over OX1 (52 nM)^[1].

IC₅₀& Target^[1]

OX2

0.13 nM (EC₅₀)

OX1

52 nM (EC₅₀)

分子量

2857.26

Formula

C₁₂₀H₂₀₆N₄₄O₃₅S

CAS 号

532932-99-3

Sequence

Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Sequence Shortening

RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.