ML337

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ML337

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1443118-44-2

ML337 是一种选择性和脑渗透性的mGlu3的负变构调节剂，IC₅₀值为 593 nM。ML337 具有良好的营养不良性肌强直蛋白激酶 (DMPK) 和辅助药理学特征。

生物活性

ML337 is a selective and brain-penetrant negative allosteric modulator ofmGlu3, with anIC₅₀of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile^[1].

IC₅₀& Target^[1]

mGluR3

593 nM (IC₅₀)

体外研究
(In Vitro)

ML337 has no activity at mGlu1, 2, 4, 5, 6, 7 and 8 at concentrations up to 30 μM^[1].

分子量

353.39

Formula

C₂₁H₂₀FNO₃

CAS 号

1443118-44-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.