L-DOPA sodium

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L-DOPA sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

63302-01-2

Levodopa sodium
3,4-Dihydroxyphenylalanine sodium

L-DOPA (Levodopa) sodium 是一种具有口服活性的神经递质多巴胺的代谢前体。L-DOPA sodium 可以透过血脑屏障，并在大脑中转化为多巴胺。L-DOPA sodium 具有抗痛觉过敏作用，可用于帕金森氏病的研究。

生物活性

L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research^[1]^[2]^[3].

IC₅₀& Target

Human Endogenous Metabolite

体内研究
(In Vivo)

L-DOPA sodium (20 mg/kg; orally) reduces Rotenone-induced motor dysfunction^[3].
L-DOPA sodium (0-100 mg/kg; orally) reverses tactile, cold and heat allodynia in neuropathic rat without any side effect in sprague-Dawley rats^[4].

Animal Model:	C57BL/6J mice (7-week-old)^[3]
Dosage:	20 mg/kg
Administration:	Orally
Result:	Reduced Rotenone-induced motor dysfunction.

Animal Model:	Sprague-Dawley rats^[4]
Dosage:	10, 30, 50, 70, and 100 mg/kg
Administration:	Orally
Result:	Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.

Clinical Trial

分子量

219.17

Formula

C₉H₁₀NNaO₄

CAS 号

63302-01-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.