Debio 0617B 是一种多激酶抑制剂，可减少原代人 AML CD34+干/祖细胞的维持和自我更新。Debio 0617B 靶向 STAT3/STAT5 信号上游关键激酶，如 JAK、SRC、ABL 和 III/V 类受体酪氨酸激酶。Debio 0617B 在 STAT3 驱动的实体瘤中具有功效。
| 生物活性 | Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AMLCD34+ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such asJAK,SRC,ABL, and class III/Vreceptor tyrosine kinases(TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors[1]. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
