(-)-Cleistenolide

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(-)-Cleistenolide

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1003600-48-3

Cleistenolide

(-)-Cleistenolide 是一种 α,β- 不饱和 δ- 内酯，从Cleistochlamys kirkiiOliver 中分离得到。(-)-Cleistenolide 具有抗菌和抗肿瘤活性。

生物活性

(-)-Cleistenolide is a α,β-unsaturated δ-lactone isolated fromCleistochlamys kirkiiOliver. (-)-Cleistenolide has antibacterial and antitumor activity^[1].

体外研究
(In Vitro)

(-)-Cleistenolide (compound 1) exhibits potent cytotoxicity against cancer cell lines and low cytotoxicity in normal cells MRC-5^[1].

Cell Cytotoxicity Assay

Cell Line:	K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa, A549 and MRC-5^[1]
Concentration:	0-100 μM
Incubation Time:
Result:	Exhibited potent cytotoxicity against cancer cell lines with IC₅₀s of 7.65 μM, 1.21 μM, 14.22 μM, 36.94 μM, 26.07 μM, 2.25 μM, 7.32 μM and 16.34 μM in K562, HL-60, Jurkat, Raji, MCF-7, MDA-MB 231, HeLa and A549, respectively; and had low cytotoxicity in normal cells MRC-5 with an IC₅₀over 100 μM.

分子量

362.33

Formula

C₁₈H₁₈O₈

CAS 号

1003600-48-3

结构分类

Antibiotics
Beta-lactam Antibiotics

来源

Plants

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.