Chromenone 1 是一种有效的成骨骨形态发生蛋白(BMP)增强剂。Chromenone 1 表现出独特的作用模式，因为它诱导了显著的、非激酶依赖的、负的 TGFβ 反馈，从而增强了核 BMP-Smad 信号输出。
| 生物活性 | Chromenone 1 is a potent osteogenicbone morphogenetic protein(BMP)potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1]. |
体外研究
(In Vitro) | Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts[1].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
